Therapeutic Applications of Cell Adhesion Inhibitors
نویسندگان
چکیده
منابع مشابه
Therapeutic applications of glycosidic carbonic anhydrase inhibitors.
The zinc enzymes carbonic anhydrases (CAs, EC 4.2.1.1) are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate and hence play an important physiological role. In humans, 16 different isozymes have been described, some of them being involved in various pathological disorders. Several of these isozymes are considered as drug targets, and the design of selective ...
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10.2217/14750708.4.3.355 © 2 Inhibitors of the zinc enzyme carbonic anhydrase (CA) targeting different isozymes among the 15 presently reported in humans have various therapeutic applications. These enzymes are efficient catalysts for the hydration of carbon dioxide to bicarbonate and protons, playing crucial physiological/pathological roles related to acid–base homeostasis, secretion of electr...
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Three compounds, NP25301 (1), NP25302 (2) and bohemamine (3), inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044. New compounds 1 and 2 were identified as 2-(3'-carbamoylphenoxy)acrylic acid methyl ester and deoxybohemamine, respectively, based on spectroscopic analyses. Compounds 1 approximately 3 inhibited adhesion o...
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Platelet aggregation, in fundamental terms, is considered a biological end point that contributes to the occurrence of clinical events among patients with advanced atherosclerotic coronary artery disease. Acute coronary syndrome, including non–ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI), accounts for upward of 733 000 hospital admissions yearly in ...
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The ability to control the placement of mammalian cells is important for many commercial and research applications. Any attempt to constrain normal mammalian cells will have functional consequences and will require an understanding of the basic mechanisms underlying adhesion between cells and their underlying substratum. We describe the current model of cell adhesion and the use of micropattern...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1997
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.24.12_797